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KMID : 0379520040200030281
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한국독성학회지
2004 Volume.20 No. 3 p.281 ~ p.292
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Single and Five-Week Oral Dose Toxicity Studies of Calcitriol and Alendronate Mixtures in Rats
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Moon Sung-Won
Jin Ji-Yun
Lee Jin-Hee
Sim Sang-Soo
Kim Chang-Jong
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Abstract
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The purpose of this study was to assess the single and 5 week oral dose toxicity of calcitriol and alendronate combination (1 : 10,000) treatment for osteoporosis or Paget’s disease in male and female rats. In single dose oral toxicity study, the values of LD_{50} of calcitriol and alendronate mixture were 750.075 mg/kg in male rats and 775.0775 mg/kg in female rats, respectively. Body weight and food consumption were continuously increased after adminstration of calcitriol and alendronate mixtures, and there was no significant changes in body weight and food consumption in all groups. In five-week oral toxicity study of calcitriol and alendronate mixture at a dose of 0.2 mutextrm{g} + 2 mg, 1 mutextrm{g} + 10 mg, 5 mutextrm{g} + 50 mg and 25 mutextrm{g} + 250 mg, respectively, there was no mortality, abnormal behavior and appearance in all groups throughout the administration period (5 weeks) and recovery period (2 weeks). Dose-dependent changes in parameters of urinalysis and hematological analysis were not observed in male and female rats treated with calcitriol and alendronate mixtures. All the values of the parameters appeared to be in the normal range. These data indicate that both calcitriol and alendronate are drugs having low toxicity in rats. NOAEL of calcitriol and alendronate mixtures were 50.005 mg/kg in 5-week oral toxicity.
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KEYWORD
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Alendronate, Calcitriol, Single oral dose toxicity, LD_{50}, Five-week oral dose toxicity
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